Sister chromatid exchange frequencies in patients with scleroderma and their relatives.
نویسندگان
چکیده
Sister chromatid exchange (SCE) analysis is a sensitive measure of chromosome damage induced by many agents which damage DNA. These agents have been reported to be present in the serum of patients with scleroderma. Chromosome aberrations are thought to be more common in cells of these patients and their relatives than in cells of controls. We have observed that the SCE frequencies in blood lymphocytes of patients with scleroderma and their relatives do not differ from those of controls.
منابع مشابه
Sister chromatid exchange analysis in some Holstein bulls
Chromosomal appearance of 12 Holstein bulls selected for artificial inseminations were examined bysister chromatid exchanges (SCEs). For differential staining of sister chromatids bromodeoxyuridine (BrdU)was inoculated in lymphocyte cultures. The mean, maximum and minimum number of SCE per cell weredetermined 6.8 ± 1.14, 8.3 ± 1.1 and 5.7 ± 1.5, respectively. SCE frequencies of all animals were...
متن کاملIncreased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives
Gastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and ...
متن کاملStudy of the Effect of MMC on the Sister Chromatid Exchange in the Human Lymphocytes
Some environmental mutagenic agents cause genomic instability and increase susceptibility of DNA damage. One of them is mitomycin C which is connected to DNA as an alkylating factor and affects susceptible cells to reduction reactions. This drug is used in chemotherapy and treatment of tumors. Study of genomic instability in the presence of different concentrations of MMC can show susceptibilit...
متن کاملSome Observations on Spontaneous Sister Chromatid Exchange Frequencies and Cell Cycle Progression in Stimulated Lymphocytes of Patients With Different Malignancies
Total 23 patients with different malignancies viz. Ca. Lung (5), Ca. Uterine & Cervix (5), Ca. Head & Neck (5), Sarcomas (5) and Malignant Melanoma (3); were studied for spontaneous sister chromatid exchange frequencies (SCE) as well as cell cycle progression. All blood samples were collected prior to chemotherapy and/or radiotherapy to exclude the influence of these therapies, if any, on SCEs....
متن کاملAssociation of sister chromatid exchange frequencies in patients with ankylosing spondylitis with and without HLA-B27.
BACKGROUND The analysis of sister chromatid exchange (SCE) is a cytogenetic technique used to show DNA damage due to an exchange of DNA fragments between sister chromatids. OBJECTIVE To determine whether HLA-B27 positive patients with ankylosing spondylitis (AS) were associated with higher SCE frequencies than patients without B27. METHODS Lymphocytes from 38 patients with AS (15 women, 23 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Annals of the rheumatic diseases
دوره 45 5 شماره
صفحات -
تاریخ انتشار 1986